comparative efficacy of meloxicam and placebo in vasospasm of patients with subarachnoid hemorrhage

نویسندگان

seyed mohammad ghodsi department of neurosurgery, tehran university of medical sciences

niayesh mohebbi department of clinical pharmacy, faculty of pharmacy, and research center for rational use of drugs, tehran university of medical sciences

soheil naderi tehran university of medical sciences

mousareza anbarloie department of neurosurgery, tehran university of medical sciences

چکیده

cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (sah).despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. inflammation is believed to play an important role in post-haemorrhagic vasospasm. meloxicam is a non-steroidal anti-inflammatory drug. the aim of this study was to compare the efficacy of meloxicam versus placebo on vasospasm in patients with sah. in this randomized, double-blind, placebo-controlled trial, sah patients randomly received 7.5 mg meloxicam or placebo twice daily for 7 days. end points were, middle cerebral artery velocity obtained with transcranial doppler, in-hospital mortality, hospital stay and discharge glasgow outcome scale. eighty-one patients enrolled in the study. (40 received meloxicam, 41 received placebo). baseline characteristics were similar between the groups. there were no differences in, length of hospitalization (17.4 ± 3.1 vs 18.6 ± 4.2 days; p = 0.145), in-hospital mortality rate (15 vs 22%; p-value=0.569), or gos (p = 0.972) between the two groups. mca velocity were slightly less in patients who had received meloxicam, but not to a significant degree (p-value=0. 564(. no side effect has been detected for meloxicam. this study did not prove meloxicam efficacy in vasospasm of sah patients. but it demonstrated that clinical trial of meloxicam in these patients is feasible and probably safe. the effectiveness of meloxicam on cerebral vasospasm has to be studied in larger trials.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparative Efficacy of Meloxicam and Placebo in Vasospasm of Patients with Subarachnoid Hemorrhage

Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...

متن کامل

Comparative Efficacy of Meloxicam and Placebo in Vasospasm of Patients with Subarachnoid Hemorrhage

Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...

متن کامل

Comparative Efficacy of Meloxicam and Placebo in Vasospasm of Patients with Subarachnoid Hemorrhage

Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...

متن کامل

Sodium Balance and Symptomatic Vasospasm in Patients with Subarachnoid Hemorrhage

Hyponatremia is a common complication after subarachnoid hemorrhage. Although the mechanism of hyponatremia is still controversial, cerebral salt wasting syndrome is currently more favored over the the syndrome of inappropriate secretion of antidiuretic hormone. To accurately manage body water and electrolytes in the acute stage of subarachnoid hemorrhage, we prospectively studied the relations...

متن کامل

Vasospasm After Subarachnoid Hemorrhage

Background and Purpose—Vasospasm secondary to subarachnoid hemorrhage (SAH) is responsible for severe ischemic complications. Although effective, angioplasty must be performed at a very early stage to produce any clinical recovery. Diagnostic investigations to assess arterial narrowing (transcranial Doppler, angiography) or cerebral perfusion (xenon CT, single-photon emission CT) do not provide...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۴، شماره ۱، صفحات ۱۲۵-۱۳۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023